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DHFR-IN-19

CAT: 0804-HY-162656Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-162656Size:1 Each
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Description
DHFR-IN-19 (Compound 2g) is a selective inhibitor for TbDHFR with Ki of 9 nM. DHFR-IN-19 exhibits antiparasitic activity against Trypanosoma brucei with an EC50 of 14.5 μM[1].
CAS Number
41927-06-4
UNSPSC
12352211
Hazard Statement
H302-H315-H319-H335
Target
Dihydrofolate reductase (DHFR)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/dhfr-in-19.html
Smiles
NC(NC1=NC2=CC(C)=C(C)C=C2N1)=N
Molecular Formula
C10H13N5
Molecular Weight
203.24
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Francesconi V, et al., Identification of Innovative Folate Inhibitors Leveraging the Amino Dihydrotriazine Motif from Cycloguanil for Their Potential as Anti-Trypanosoma brucei Agents. ACS Infect Dis. 2024 Jul 2.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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