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DHFR-IN-22

CAT: 0804-HY-159899Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-159899Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DHFR-IN-22 (Compound 8) is a DHFR (Dihydrofolate Reductase) inhibitor belonging to the class of 2,4-diaminopyrimidine compounds. DHFR-IN-22 exhibits significant inhibitory activity against purified DHFR enzyme and major species of nontuberculous mycobacteria (NTM), namely Mycobacterium avium and Mycobacterium abscessus. It shows an IC50 of 1.1 nM and MIC of 1.5 μg/mL against M. abscessus, and an IC50 of 6.3 nM and MIC of 0.1 μg/mL against M. avium. Additionally, it demonstrates an IC50 of 2100 nM against human DHFR. DHFR-IN-22 holds potential for studying novel strategies to combat NTM infections[1].
CAS Number
2941327-87-1
UNSPSC
12352005
Target
Antibiotic; Bacterial; Dihydrofolate reductase (DHFR)
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/dhfr-in-22.html
Smiles
O=C(O)CCC1=C(OCCCOC2=C(N)N=C(N)N=C2C3CCCCC3)C=CC=C1
Molecular Formula
C22H30N4O4
Molecular Weight
414.50
References & Citations
[1]Andrade Meirelles M, et al. Rational Exploration of 2,4-Diaminopyrimidines as DHFR Inhibitors Active against Mycobacterium abscessus and Mycobacterium avium, Two Emerging Human Pathogens. J Med Chem. 2024 Nov 14;67 (21) :19143-19164.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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