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DHFR-IN-5

CAT: 0804-HY-153007-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-153007-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DHFR-IN-5 is a potent and orally active dihydrofolate reductase (DHFR) inhibitor with a Ki value of 0.54 nM for quadruple mutant Plasmodium falciparum DHFR. DHFR-IN-5 shows anti-malaria activity[1].
CAS Number
1142407-81-5
UNSPSC
12352005
Target
Dihydrofolate reductase (DHFR)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/dhfr-in-5.html
Purity
99.27
Solubility
10 mM in DMSO
Smiles
O=C(CCC1=C(OCCCOC2=C(CC)N=C(N)N=C2N)C=CC=C1)O
Molecular Formula
C18H24N4O4
Molecular Weight
360.41
References & Citations
[1]Yuthavong Y, et al. Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target. Proc Natl Acad Sci U S A. 2012 Oct 16;109 (42) :16823-8.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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