AChE-IN-51

• Description:

  AChE-IN-51 (compound 8C) is an orally active, non-competitive inhibitor of AChE and BChE (IC50: 84 nM, 97 nM) . It also inhibits MMP-2 and amyloid Aβ1-42 aggregates (IC50: 724 nM, 302 nM) . AChE-IN-51 has low cytotoxicity and in silico predicted blood-brain barrier permeability. Can be used for research on diseases such as Alzheimer's disease (AD) [1].

• UNSPSC:

  12352005

• Target:

  Amyloid-β; Cholinesterase (ChE) ; MMP

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease; Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/ache-in-51.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC(C(C=C)=P(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)=O

• Molecular Formula:

  C23H21OP

• Molecular Weight:

  344.39

• References & Citations:

  [1]El-Hussieny M, et al. Dual-target ligand discovery for Alzheimer's disease: triphenylphosphoranylidene derivatives as inhibitors of acetylcholinesterase and β-amyloid aggregation. J Enzyme Inhib Med Chem. 2023 Dec;38 (1) :2166040.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  AChE; BChE; MMP-2