AChE-IN-51

CAT: 0804-HY-157382Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-157382Size:1 Each
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Description
AChE-IN-51 (compound 8C) is an orally active, non-competitive inhibitor of AChE and BChE (IC50: 84 nM, 97 nM) . It also inhibits MMP-2 and amyloid Aβ1-42 aggregates (IC50: 724 nM, 302 nM) . AChE-IN-51 has low cytotoxicity and in silico predicted blood-brain barrier permeability. Can be used for research on diseases such as Alzheimer's disease (AD) [1].
UNSPSC
12352005
Target
Amyloid-β; Cholinesterase (ChE) ; MMP
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ache-in-51.html
Solubility
10 mM in DMSO
Smiles
CC(C(C=C)=P(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)=O
Molecular Formula
C23H21OP
Molecular Weight
344.39
References & Citations
[1]El-Hussieny M, et al. Dual-target ligand discovery for Alzheimer's disease: triphenylphosphoranylidene derivatives as inhibitors of acetylcholinesterase and β-amyloid aggregation. J Enzyme Inhib Med Chem. 2023 Dec;38 (1) :2166040.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; BChE; MMP-2

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