AChE-IN-47

• Description :

  AChE-IN-47 (compound g17) is a AChE inhibitor with the IC50 of 0.24 μM. AChE-IN-47 inhibits amyloid β peptides self-aggregation. AChE-IN-47 displays neuroprotective effects and effectively suppresses the intracellular accumulation of reactive oxygen species[1].

• UNSPSC :

  12352005

• Target :

  Cholinesterase (ChE)

• Type :

  Reference compound

• Related Pathways :

  Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/ache-in-47.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(NC1=CC=C2C(N3CCCC3=NC2=C1)=O)CNS(=O)(C4=CC=CC=C4C(F)(F)F)=O

• Molecular Formula :

  C20H17F3N4O4S

• Molecular Weight :

  466.43

• References & Citations :

  [1]Dong S, et al. Discovery of novel deoxyvasicinone derivatives with benzenesulfonamide substituents as multifunctional agents against Alzheimer's disease. Eur J Med Chem. 2024;264:116013.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  AChE

• CAS Number :

  [3033056-55-9]