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PD-1-IN-25

CAT: 0804-HY-157055Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-157055Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PD-1-IN-25 (compound 43) is a potent PD-1/PD-L1 interaction inhibitor with an IC50 value of 10.2 nM in the HTRF assay. PD-1-IN-25 can promote CD8+ T cell activation through inhibiting PD-1/PD-L1 cellular signaling. PD-1-IN-25 delays the tumor growth[1].
CAS Number
2413100-40-8
UNSPSC
12352005
Target
PD-1/PD-L1
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pd-1-in-25.html
Solubility
10 mM in DMSO
Smiles
CC1=C(C=CC=C1C(F)(F)OC2=CC(OCC3=CC(C#N)=CC=C3)=C(C=C2Cl)CN[C@H]4[C@H]([C@@H]([C@H](OC4O)CO)O)O)C5=CC=C(OCCO6)C6=C5
Molecular Formula
C37H35ClF2N2O9
Molecular Weight
725.13
References & Citations
[1]Zilan Song, et al. Design, Synthesis, and Pharmacological Evaluation of Biaryl-Containing PD-1/PD-L1 Interaction Inhibitors Bearing a Unique Difluoromethyleneoxy Linkage. J Med Chem. 2021 Nov 25;64 (22) :16687-16702.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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