PD-1/PD-L1 antagonist 1

• UNSPSC Description:

  PD-1/PD-L1 antagonist 1 (Compound A5) is an antagonist for programmed cell death-1 (PD-1) and programmed cell death ligand-1 (PD-L1) interaction, with an IC50 of 23.78 nM[1].

• Target Antigen:

  PD-1/PD-L1

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/pd-1-pd-l1-antagonist-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  ClC(C=C1CNC[C@H](CO)O)=C(C=C1OCC2=CC(C#N)=CC=C2)OCC3=CC=CC(C4=CC=CC5=C4N=CN=C5OC6=CC(OCC7=CC=CC(C#N)=C7)=C(C=C6Cl)CNC[C@H](CO)O)=C3C

• Molecular Weight:

  955.88

• References & Citations:

  [1]Wu X, et al. Design, Synthesis, and Evaluation of 8-(o-Tolyl) quinazoline Derivatives as Small-Molecule PD-1/PD-L1 Antagonists[J]. ACS Medicinal Chemistry Letters, 2024.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported