PROTAC ERα Degrader-6

• UNSPSC Description:

  PROTAC ERα Degrader-6 (compound A2) is a potent PROTAC degrader of ERα, with IC50 of 0.11 μM in MCE-7 cells. PROTAC ERα Degrader-6 has anti-tumor effect. PROTAC ERα Degrader-6 is a fluorescent probes with Em of 582 nm that enable real-time visualization of ERα protein degradation[1].

• Target Antigen:

  Estrogen Receptor/ERR; PROTACs

• Type:

  Reference compound

• Related Pathways:

  PROTAC;Vitamin D Related/Nuclear Receptor

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-erα-degrader-6.html

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  O=C(N1C[C@H](O)C[C@H]1C(N[C@@H](C)C2=CC=C(C3=C(C)N=CS3)C=C2)=O)[C@@H](NC(CCCCCCCOC4=C(C=CC(O)=C4)/C=C/C5=C/C(C6=CC(O)=CC=C6O5)=C(C#N)/C#N)=O)C(C)(C)C

• Molecular Weight:

  913.09

• References & Citations:

  [1]Xiaohua Wang, et al. Fluorescence theranostic PROTACs for real-time visualization of ERα degradation. Eur J Med Chem. 2024 Feb 1:267:116184.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported