PROTAC EGFR degrader 6

PROTAC EGFR degrader 6

• CAS Number: 2409793-28-6
• UNSPSC Description: PROTAC EGFR degrader 6, a PROTAC EGFR degrader, potently degrades EGFRDel19 in HCC827 cells with the DC50 of 45.2 nM. PROTAC EGFR degrader 6 significantly induces the apoptosis of HCC827 cells and arrest the cells in G1 phase[1].
• Target Antigen: Apoptosis; EGFR; PROTACs
• Type: Reference compound
• Related Pathways: Apoptosis;JAK/STAT Signaling;PROTAC;Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/protac-egfr-degrader-6.html
• Solubility: 10 mM in DMSO
• Smiles: O=C1CCC(C(N1)=O)N2CC3=C(C2=O)C=CC=C3NC(CCCCCCCN4CCN(CC4)C5=CC=C(N=C5)NC6=NC=C7N=C(N=C(C7=C6)N8CCC(CC8)CO)NC9=CC=C(C=C9)F)=O
• Molecular Weight: 913.05
• References & Citations: [1]Hao Zhang, et al. Discovery of potent epidermal growth factor receptor (EGFR) degraders by proteolysis targeting chimera (PROTAC). Eur J Med Chem. 2020 Mar 1;189:112061.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported