PROTAC SOS1 degrader-6

• UNSPSC Description:

  PROTAC SOS1 degrader-6 (compound 23) is an effective SOS1 PROTACs degrader that synergizes with KRASG12C inhibitors[1]. PROTAC SOS1 degrader-6 consists of the target protein ligand (red part) SOS1 Ligand intermediate-7 (HY-169371), E3 ubiquitin ligase ligand (blue part) (S,R,S)-AHPC (HY-125845), and PROTAC linker (black part) 5-Bromopentanoic acid (HY-W016456). Among them, the E3 ubiquitin ligase ligand + linker can form (S,R,S)-AHPC-CO-C4-bromine (HY-169372).

• Target Antigen:

  PROTACs; Ras

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;MAPK/ERK Pathway;PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-sos1-degrader-6.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC1=NC2=C(C=C(C(OC)=C2)OCCCCC(N[C@@H](C(C)(C)C)C(N3C[C@H](O)C[C@H]3C(NCC4=CC=C(C5=C(C)N=CS5)C=C4)=O)=O)=O)C(N[C@H](C)C6=CC(N)=CC(C(F)(F)F)=C6)=N1

• Molecular Weight:

  905.04

• References & Citations:

  [1]Lv Y, et al. A Potent SOS1 PROTAC Degrader with Synergistic Efficacy in Combination with KRASG12C Inhibitor. J Med Chem. 2024 Feb 22;67(4):2487-2511.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  3032282-51-9