PROTAC SOS1 degrader-6

PROTAC SOS1 degrader-6

• CAS Number: 3032282-51-9
• UNSPSC Description: PROTAC SOS1 degrader-6 (compound 23) is an effective SOS1 PROTACs degrader that synergizes with KRASG12C inhibitors[1]. PROTAC SOS1 degrader-6 consists of the target protein ligand (red part) SOS1 Ligand intermediate-7 (HY-169371), E3 ubiquitin ligase ligand (blue part) (S,R,S)-AHPC (HY-125845), and PROTAC linker (black part) 5-Bromopentanoic acid (HY-W016456). Among them, the E3 ubiquitin ligase ligand + linker can form (S,R,S)-AHPC-CO-C4-bromine (HY-169372).
• Target Antigen: PROTACs; Ras
• Type: Reference compound
• Related Pathways: GPCR/G Protein;MAPK/ERK Pathway;PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: cancer
• Assay Protocol: https://www.medchemexpress.com/protac-sos1-degrader-6.html
• Solubility: 10 mM in DMSO
• Smiles: CC1=NC2=C(C=C(C(OC)=C2)OCCCCC(N[C@@H](C(C)(C)C)C(N3C[C@H](O)C[C@H]3C(NCC4=CC=C(C5=C(C)N=CS5)C=C4)=O)=O)=O)C(N[C@H](C)C6=CC(N)=CC(C(F)(F)F)=C6)=N1
• Molecular Weight: 905.04
• References & Citations: [1]Lv Y, et al. A Potent SOS1 PROTAC Degrader with Synergistic Efficacy in Combination with KRASG12C Inhibitor. J Med Chem. 2024 Feb 22;67(4):2487-2511.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported