AMPK activator 6

• Description:

  AMPK activator 6 (Compound GC) reduces lipid content and activates the AMPK pathway in HepG2 and 3T3-L1 cells. AMPK activator 6 significantly suppresses the increase in triglyceride (TG), total cholesterol (TC), low-density lipoprotein-C (LDL-C), and other biochemical indices in blood serum. AMPK activator 6 can be used for the research of non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome[1].

• UNSPSC:

  12352005

• Target:

  AMPK

• Type:

  Reference compound

• Related Pathways:

  Epigenetics; PI3K/Akt/mTOR

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/ampk-activator-6.html

• Solubility:

  10 mM in DMSO

• Smiles:

  C/C(C)=C\CC/C(C)=C\CC1=C(C=C(C(C(/C=C/C2=CC=C(C=C2)O)=O)=C1O)O)O

• Molecular Formula:

  C25H28O5

• Molecular Weight:

  408.49

• References & Citations:

  [1]Mengdi Zhang, et al. Synthesis of natural 3'-Prenylchalconaringenin and biological evaluation of ameliorating non-alcoholic fatty liver disease and metabolic syndrome. Eur J Med Chem. 2020 Nov 1;205:112649.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  189299-03-4