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MAO-B-IN-26

CAT: 0804-HY-156348Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-156348Size:1 Each
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Description
MAO-B-IN-26 (Compound IC9) is a MAO-B and acetylcholinesterase inhibitor. MAO-B-IN-26 protects SH SY5Y cells against Aβ induced cytotoxicity, morphological changes, ROS generation and membrane damage. MAO-B-IN-26 also inhibits Aβ induced autophagy and apoptosis. MAO-B-IN-26 can be used as a neuroprotective agent against Alzheimer’s disease[1].
CAS Number
38470-71-2
UNSPSC
12352005
Target
Apoptosis; Autophagy; Cholinesterase (ChE) ; Monoamine Oxidase
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mao-b-in-26.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CNC2=C1C=CC=C2)/C=C/C3=CC=C(Br)C=C3
Molecular Formula
C17H12BrNO
Molecular Weight
326.19
References & Citations
[1]Sasidharan R, et al. MAO-B Inhibitor (2E) -3- (4-Bromophenyl) -1- (1H-indol-3-yl) prop-2-en-1-one as a Neuroprotective Agent Against Alzheimer's Disease. Neurochem Res. 2023 Oct 9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Mao-B-IN-26
CAS Number38470-71-2
PubChem CID15122797
IUPAC Name(E)-3-(4-bromophenyl)-1-(1H-indol-3-yl)prop-2-en-1-one
Molecular FormulaC17H12BrNO
Molecular Weight326.2
XLogP4.8
Topological Polar Surface Area32.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count1
Rotatable Bond Count3
Heavy Atom Count20
Formal Charge0
Complexity373
SMILES
C1=CC=C2C(=C1)C(=CN2)C(=O)/C=C/C3=CC=C(C=C3)Br
InChI
InChI=1S/C17H12BrNO/c18-13-8-5-12(6-9-13)7-10-17(20)15-11-19-16-4-2-1-3-14(15)16/h1-11,19H/b10-7+
InChIKey
RVUJDYIDVJKIFK-JXMROGBWSA-N
Chemical Structure
2D Structure
2D structure of Mao-B-IN-26
CAS: 38470-71-2
CID: 15122797
Formula: C17H12BrNO
MW: 326.2
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight326.2
XLogP34.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count1
Rotatable Bond Count3
Exact Mass325.01023
Monoisotopic Mass325.01023
Topological Polar Surface Area32.9 Ų
Heavy Atom Count20
Formal Charge0
Complexity373
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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