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MAO-B-IN-4

CAT: 0804-HY-143330Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-143330Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MAO-B-IN-4 (Compound 26) is an orally active and reversible MAO-B inhibitor with an IC50 of 9 nM. MAO-B-IN-4 has good metabolic stability, safety profile and brain permeability. MAO-B-IN-4 shows antidepressant activity in rats and mice. MAO-B-IN-4 can be used in studies related to Alzheimer's disease[1].
UNSPSC
12352005
Target
Monoamine Oxidase
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mao-b-in-4.html
Solubility
10 mM in DMSO
Smiles
FC1(CCN(CC1)C2=NC3=CC=CC=C3C4=C2C=CN4CC5=CC(Cl)=CC=C5)F
Molecular Formula
C23H20ClF2N3
Molecular Weight
411.87
References & Citations
[1]Grychowska K, et al. Overcoming undesirable hERG affinity by incorporating fluorine atoms: A case of MAO-B inhibitors derived from 1 H-pyrrolo-[3,2-c]quinolines. Eur J Med Chem. 2022 Jun 5;236:114329.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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