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MAO-B-IN-45

CAT: 0804-HY-176271Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-176271Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MAO-B-IN-45 is a dual inhibitor of ferroptosis and MAO-B. MAO-B-IN-45 shows selectivity towards MAO-B with an IC50 of 87.47 nM and selectivity exceeding 229-fold for MAO-B over MAO-A. MAO-B-IN-45 has excellent antiferroptosis activity through modulation of the iron metabolic pathway and GSH-GPX4 axis in vitro. MAO-B-IN-45 improves cognitive and behavioral impairments in 3xTg (APP/Tau/Ps1) AD mouse and significantly reduced the levels of ferritin heavy chain 1 (FTH1), APP, and Tau phosphorylation (p-Tau) proteins in the brain[1].
CAS Number
3069915-36-9
UNSPSC
12352005
Target
Amyloid-β; Ferroptosis; Glutathione Peroxidase; Monoamine Oxidase; Reactive Oxygen Species (ROS) ; Tau Protein
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
CN1C(C(O)=CC2=CC=C(C=C21)OCC3=CC=C(C=C3)Cl)=O
Molecular Formula
C17H14ClNO3
Molecular Weight
315.75
References & Citations
[1]Lv Y, et al. 3-Hydroxyquinolin-2-Ones Act as Dual Inhibitors of Ferroptosis and Monoamine Oxidase B: Reducing Alzheimer's Disease-Related Amyloid Precursor Protein and Hyperphosphorylated Tau In Vivo. J Med Chem. 2025 Jun 21.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GPX4; MAO-B

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