Products for Research Use Only
RegisterLogin

MAO-B-IN-46

CAT: 0804-HY-W207699Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-W207699Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
MAO-B-IN-46 (Compound 16) is a selective hMAO-B inhibitor (IC50: 26.8 nM), with weak activity against hMAO-A (IC50: 7.2054 μM) . MAO-B-IN-46 (Compound 8) also acts as an α-amylase inhibitor (IC50: 19.46 μM) . MAO-B-IN-46 exhibits certain neuroprotective effects and shows no significant toxicity to human gingival fibroblasts and SH-SY5Y cells. Additionally, MAO-B-IN-46 can scavenge DPPH and ABTS free radicals, with IC50 values of 17.86 μM and 17.71 μM, respectively. MAO-B-IN-46 can be used in the research of neurodegenerative diseases such as Parkinson's disease, diabetes, and diseases related to oxidative stress resistance[1][2].
CAS Number
27052-20-6
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Amylases; Monoamine Oxidase
Related Pathways
Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology; Neurological Disease
Smiles
C1=CC=C2C(=C1)C=C(C(=O)C3=CC=C(C=C3)Cl)O2
Molecular Formula
C15H9ClO2
Molecular Weight
256.68
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Guglielmi P, et al. Design, synthesis, and biological activity of 2-aroylbenzofuran-3-ols and 2-aroylbenzofuran derivatives: A new route towards hMAO-B inhibition. Eur J Med Chem. 2025 Nov 5;297:117983.|[2]Ali I, et al. Potent α-amylase inhibitors and radical (DPPH and ABTS) scavengers based on benzofuran-2-yl (phenyl) methanone derivatives: Syntheses, in vitro, kinetics, and in silico studies. Bioorg Chem. 2020 Nov;104:104238.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAO-A; MAO-B

Related Products

CatalogName
HY-W628136MAO-B-IN-47
HY-149234-01MAO-B-IN-18
HY-146149MAO-B-IN-11
HY-168138MAO-B-IN-34
HY-143330MAO-B-IN-4
HY-146347MAO-B-IN-10
HY-151208MAO-B-IN-16
HY-151209MAO-B-IN-15
HY-149820MAO-B-IN-22
HY-176271MAO-B-IN-45

Alternative Products

CatalogName
T212299-01MAO-B-IN-46
B2919-5MAO-A/MAO-B Inhibitor
YP-W19977-01Human MAO-B (MAO-B) ELISA Kit
YP-W200865-01Mouse MAO-B (MAO-B) ELISA Kit
YP-W35915-01Rat MAO-B (MAO-B) ELISA Kit
sc-515575MAO-B (B-8)
M37657-01MAO-B-IN-5
M35454-01MAO-B-IN-9
BA8520-25MAO-B-IN-2
T200499-01MAO-B-IN-34

Popular Products