MAO-B-IN-10

• UNSPSC Description:

  MAO-B-IN-10 (compound 4f) is a potent, selective, BBB-penetrated MAO-B (monoamine oxidase-B) inhibitor, with IC50 of 5.3 μM. MAO-B-IN-10 can inhibit (58.2%) and disaggregate (43.3%) self-mediated Aβ (amyloid β) aggregation. MAO-B-IN-10 can be use for Alzheimer’s disease research[1].

• Target Antigen:

  Amyloid-β; Monoamine Oxidase

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/mao-b-in-10.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CCN(C(OC1=C(C=C(C=C1)/C=C/C(N2CCC3=C(C2)C=CC=C3)=O)OC)=O)C

• Molecular Weight:

  394.46

• References & Citations:

  [1]Sang Z, et al. Design, synthesis and biological evaluation of novel O-carbamoyl ferulamide derivatives as multi-target-directed ligands for the treatment of Alzheimer's disease. Eur J Med Chem. 2020 May 15;194:112265.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2376710-36-8