MAO-B-IN-10

MAO-B-IN-10

• CAS Number: 2376710-36-8
• UNSPSC Description: MAO-B-IN-10 (compound 4f) is a potent, selective, BBB-penetrated MAO-B (monoamine oxidase-B) inhibitor, with IC50 of 5.3 μM. MAO-B-IN-10 can inhibit (58.2%) and disaggregate (43.3%) self-mediated Aβ (amyloid β) aggregation. MAO-B-IN-10 can be use for Alzheimer’s disease research[1].
• Target Antigen: Amyloid-β; Monoamine Oxidase
• Type: Reference compound
• Related Pathways: Neuronal Signaling
• Applications: Neuroscience-Neurodegeneration
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/mao-b-in-10.html
• Solubility: 10 mM in DMSO
• Smiles: CCN(C(OC1=C(C=C(C=C1)/C=C/C(N2CCC3=C(C2)C=CC=C3)=O)OC)=O)C
• Molecular Weight: 394.46
• References & Citations: [1]Sang Z, et al. Design, synthesis and biological evaluation of novel O-carbamoyl ferulamide derivatives as multi-target-directed ligands for the treatment of Alzheimer's disease. Eur J Med Chem. 2020 May 15;194:112265.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported