AChE-IN-41

• Description :

  AChE-IN-41 (Compound 2) is a compound of the Galantamine Memantine hybrid. AChE-IN-41 has the inhibition ability of cholinesterase. AChE-IN-41 shows higher plasma stability and comparable microsomal stability in vitro, while showing lower half-life and faster clearance in vivo[1].

• CAS Number :

  [3038811-77-4]

• UNSPSC :

  12352005

• Target :

  Cholinesterase (ChE)

• Type :

  Reference compound

• Related Pathways :

  Neuronal Signaling

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/ache-in-41.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O[C@H]1C=C[C@@]23C(C(CN(C/C=C/CN[C@@]45C[C@]6(C)C[C@@](C5)(C)C[C@@H](C6)C4)CC3)=CC=C7OC)=C7O[C@H]2C1

• Molecular Formula :

  C32H44N2O3

• Molecular Weight :

  504.70

• References & Citations :

  [1]Basagni F, et al. Galantamine-memantine hybrids for Alzheimer's disease: The influence of linker rigidity in biological activity and pharmacokinetic properties. Eur J Med Chem. 2023 Sep 12;261:115803.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported