AChE-IN-41

• Description:

  AChE-IN-41 (Compound 2) is a compound of the Galantamine Memantine hybrid. AChE-IN-41 has the inhibition ability of cholinesterase. AChE-IN-41 shows higher plasma stability and comparable microsomal stability in vitro, while showing lower half-life and faster clearance in vivo[1].

• UNSPSC:

  12352005

• Target:

  Cholinesterase (ChE)

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/ache-in-41.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O[C@H]1C=C[C@@]23C (C (CN (C/C=C/CN[C@@]45C[C@]6 (C) C[C@@] (C5) (C) C[C@@H] (C6) C4) CC3) =CC=C7OC) =C7O[C@H]2C1

• Molecular Formula:

  C32H44N2O3

• Molecular Weight:

  504.70

• References & Citations:

  [1]Basagni F, et al. Galantamine-memantine hybrids for Alzheimer's disease: The influence of linker rigidity in biological activity and pharmacokinetic properties. Eur J Med Chem. 2023 Sep 12;261:115803.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  3038811-77-4