DHFR-IN-9

CAT: 0804-HY-156123Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-156123Size:1 Each
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Description
DHFR-IN-9 (compound 8A) is a dihydrofolate reductase (DHFR) inhibitor that affects purine and thymidylate biosynthesis in cell proliferation and growth. DHFR-IN-9 inhibits methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300 (IC50=0.25 μg/mL) and has anti-infective effects in mouse models of systemic infection and thigh infection caused by it (dose: 2.5 mg /kg, 5 mg/kg; ip) . DHFR-IN-9 has stronger anticancer activity than paclitaxel (Y-B0015) in a mouse model of breast cancer (dose: 2.5 mg/kg; ip; once every 3 days) [1].
CAS Number
[3032441-13-4]
UNSPSC
12352005
Target
Bacterial; Dihydrofolate reductase (DHFR)
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/dhfr-in-9.html
Solubility
10 mM in DMSO
Smiles
NC1=NC2=C(C(N)=N1)C(C=C(C)N3CC4=NC5=CC=CC=C5S4)=C3C=C2
Molecular Formula
C19H16N6S
Molecular Weight
360.44
References & Citations
[1]Zhu Z, et al. Exploration and Biological Evaluation of 1, 3-Diamino-7 H-pyrrol [3, 2-f] quinazoline Derivatives as Dihydrofolate Reductase Inhibitors[J]. Journal of Medicinal Chemistry, 2023.. . .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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