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DHFR-IN-11

CAT: 0804-HY-156414Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-156414Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DHFR-IN-11 (compound 6b) is inhibitor of DHFR, and has inhibitory potency versus M. tuberculosis DHFR enzyme with IC50 values 5.70 μM[1].
UNSPSC
12352005
Target
Dihydrofolate reductase (DHFR)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/dhfr-in-11.html
Solubility
10 mM in DMSO
Smiles
O=C1N=C(N2N=C(C3=CC=CS3)CC2C4=CC(OC)=CC=C4OC)SC1
Molecular Formula
C18H17N3O3S2
Molecular Weight
387.48
References & Citations
[1]Dawood DH, et, al. New Thiophenyl-pyrazolyl-thiazole Hybrids as DHFR Inhibitors: Design, Synthesis, Antimicrobial Evaluation, Molecular Modeling, and Biodistribution Studies. ACS Omega. 2023 Oct 13;8 (42) :39250-39268.|[2]Dawood DH, et al. New Thiophenyl-pyrazolyl-thiazole Hybrids as DHFR Inhibitors: Design, Synthesis, Antimicrobial Evaluation, Molecular Modeling, and Biodistribution Studies. ACS Omega. 2023;8 (42) :39250-39268. Published 2023 Oct 13.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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