DHFR-IN-9

• Target:

  Others|||DHFR|||Antibacterial

• Related Pathways:

  Others|||Metabolism|||Microbiology/Virology|||DNA Damage/DNA Repair|||Cell Cycle/Checkpoint

• Bioactivity:

  DHFR-IN-9 (compound 8A), a dihydrofolate reductase (DHFR) inhibitor, impedes purine and thymidylate biosynthesis, pivotal in cell proliferation and growth. It demonstrates potency against methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300 with an IC50 of 0.25 ?g/mL and exhibits anti-infective properties in mouse systemic and thigh infection models at doses of 2.5 mg/kg and 5 mg/kg administered intraperitoneally (ip) . Furthermore, DHFR-IN-9 shows greater anticancer efficacy in a mouse breast cancer model compared to paclitaxel (Y-B0015), at a regimented dosage of 2.5 mg/kg ip every three days [1].

• Molecular Formula:

  C19H16N6S

• Molecular Weight:

  360.44

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C