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DHFR-IN-23

CAT: 0804-HY-173220Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-173220Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DHFR-IN-23 (compound 5) is a dual DNA binders/DHFR inhibitor, with an IC50 of 0.08 μM for hDHFR. DHFR-IN-23 (compound 5) is also an apoptosis inducer. DHFR-IN-23 (compound 5) can be used for the research of ER+ breast cancer[1].
UNSPSC
12352005
Target
Apoptosis; Dihydrofolate reductase (DHFR)
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
O=C(O)C(/C=C/C1=CC=C(Cl)C=C1)=N\NC2=NC(C3=CC=CC=C3)=CS2
Molecular Formula
C19H14ClN3O2S
Molecular Weight
383.85
References & Citations
[1]Marwa H, et al. Rational design, synthesis, and molecular modelling insights of dual DNA binders/DHFR inhibitors bearing arylidene-hydrazinyl-1,3-thiazole scaffold with apoptotic and anti-migratory potential in breast MCF-7 cancer cells. Journal of Enzyme Inhibition and Medicinal Chemistry Volume 40, 2025 - Issue 1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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