PD-1/PD-L1-IN-41

PD-1/PD-L1-IN-41

• UNSPSC Description: PD-1/ PD-L1-in-41 (Compound 5c) is a PD-L1 and PD-1 inhibitor with IC50 value of 10.2 nM[1].
• Target Antigen: PD-1/PD-L1
• Type: Reference compound
• Related Pathways: Immunology/Inflammation
• Applications: COVID-19-immunoregulation
• Field of Research: Cancer; Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/pd-1-pd-l1-in-41.html
• Solubility: 10 mM in DMSO
• Smiles: CC1=C(C=CC=C1C2=CC=C3OCCOC3=C2)COC4=CC(OCC5=CC(C#N)=NC=C5)=C(CN(CCO)C)C=C4Cl
• Molecular Weight: 586.08
• References & Citations: [1]Bamminger K, et al. Development and In Vivo Evaluation of Small-Molecule Ligands for Positron Emission Tomography of Immune Checkpoint Modulation Targeting Programmed Cell Death 1 Ligand 1. J Med Chem. 2024;67(5):4036-4062.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported