PD-1/PD-L1-IN-41

• UNSPSC Description:

  PD-1/ PD-L1-in-41 (Compound 5c) is a PD-L1 and PD-1 inhibitor with IC50 value of 10.2 nM[1].

• Target Antigen:

  PD-1/PD-L1

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/pd-1-pd-l1-in-41.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC1=C(C=CC=C1C2=CC=C3OCCOC3=C2)COC4=CC(OCC5=CC(C#N)=NC=C5)=C(CN(CCO)C)C=C4Cl

• Molecular Weight:

  586.08

• References & Citations:

  [1]Bamminger K, et al. Development and In Vivo Evaluation of Small-Molecule Ligands for Positron Emission Tomography of Immune Checkpoint Modulation Targeting Programmed Cell Death 1 Ligand 1. J Med Chem. 2024;67(5):4036-4062.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported