PD-1/PD-L1-IN-49

• UNSPSC Description:

  PD-1/PD-L1-IN-49 (compound 1c) is a potent inhibitor of PD-1/PD-L1, with the IC50 of 77 nM. PD-1/PD-L1-IN-49 activates Jurkat T cells, reflecting successful blockade of the PD-1/PD-L1 immune checkpoint[1].

• Target Antigen:

  PD-1/PD-L1

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Inflammation/Immunology

• Smiles:

  CC1=C(C2=CC3=C(C=C2)N(C)CCO3)C=CC=C1NC(C4=NC=C(CNC(CO)(CO)CO)C=C4)=O

• Molecular Weight:

  492.57

• References & Citations:

  [1]Julia Zaber, et al. N-methylmorpholine incorporation into the structure of biphenyl leads to the bioactive inhibitor of PD-1/PD-L1 interaction. Bioorg Med Chem Lett. 2024 Jul 10:110:129882.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported