PD-1/PD-L1-IN-49

PD-1/PD-L1-IN-49

• UNSPSC Description: PD-1/PD-L1-IN-49 (compound 1c) is a potent inhibitor of PD-1/PD-L1, with the IC50 of 77 nM. PD-1/PD-L1-IN-49 activates Jurkat T cells, reflecting successful blockade of the PD-1/PD-L1 immune checkpoint[1].
• Target Antigen: PD-1/PD-L1
• Type: Reference compound
• Related Pathways: Immunology/Inflammation
• Applications: COVID-19-immunoregulation
• Field of Research: Cancer; Inflammation/Immunology
• Smiles: CC1=C(C2=CC3=C(C=C2)N(C)CCO3)C=CC=C1NC(C4=NC=C(CNC(CO)(CO)CO)C=C4)=O
• Molecular Weight: 492.57
• References & Citations: [1]Julia Zaber, et al. N-methylmorpholine incorporation into the structure of biphenyl leads to the bioactive inhibitor of PD-1/PD-L1 interaction. Bioorg Med Chem Lett. 2024 Jul 10:110:129882.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported