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YXG-158

CAT: 0804-HY-155666Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-155666Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
YXG-158 (Compound 23-h) is an orally active AR degrader and CYP17A1 inhibitor. YXG-158 has AR degradation activity with DC50 value of 1.28 μM. YXG-158 can inhibit CYP17A1 with IC50 value of 100 nM. XG-158 can be used for the research of enzalutamide-resistant prostate cancer[1].
CAS Number
2952994-34-0
UNSPSC
12352005
Target
Androgen Receptor
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/yxg-158.html
Solubility
10 mM in DMSO
Smiles
C[C@@]12[C@](CC=C2N3C=C(N=C3)C)([H])[C@@]4([H])[C@@](CC1)([H])[C@@]5(C(C[C@H](CC5)NC(C6=CC=C(C=C6)F)=O)=CC4)C
Molecular Formula
C30H36FN3O
Molecular Weight
473.62
References & Citations
[1]Wang A, et al. Discovery of a Novel Bifunctional Steroid Analog, YXG-158, as an Androgen Receptor Degrader and CYP17A1 Inhibitor for the Treatment of Enzalutamide-Resistant Prostate Cancer. J Med Chem. 2023 Jul 27;66 (14) :9972-9991.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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