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ODN 1585

CAT: 0804-HY-150725-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-150725-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ODN 1585 is a potent inducer of IFN and TNFα production. ODN 1585 is a potent stimulator of NK (natural killer) function. ODN 1585 increases CD8+ T-cell function, including the CD8+ T cell-mediated production of IFN-γ. ODN 1585 induces regression of established melanomas in mice. ODN 1585 can confer complete protection against malaria in mice. ODN 1585 can be used for acute myelogenous leukemia (AML) and malaria research. ODN 1585 can be used as a vaccine adjuvant[1][2][3].
CAS Number
386832-46-8
UNSPSC
12352208
Target
IFNAR; TNF Receptor
Type
Oligonucleotides
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/odn-1585.html
Purity
93.90
Solubility
H2O : 20 mg/mL (ultrasonic)
Smiles
[DNA,d(G-sp-G-G-G-T-C-A-A-C-G-T-T-G-A-G-G-sp-G-sp-G-sp-G-sp-G)]
Molecular Weight
6430.00
References & Citations
[1]Gramzinski RA, et al. Interleukin-12- and gamma interferon-dependent protection against malaria conferred by CpG oligodeoxynucleotide in mice. Infect Immun. 2001 Mar;69 (3) :1643-9.|[2]Blazar BR, et al. Synthetic unmethylated cytosine-phosphate-guanosine oligodeoxynucleotides are potent stimulators of antileukemia responses in naive and bone marrow transplant recipients. Blood. 2001 Aug 15;98 (4) :1217-25.|[3]Krug A, et al. Identification of CpG oligonucleotide sequences with high induction of IFN-alpha/beta in plasmacytoid dendritic cells. Eur J Immunol. 2001 Jul;31 (7) :2154-63.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported
Isoform
TNFRSF5/CD40

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