EGFR-IN-158

CAT: 0804-HY-172795Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-172795Size:1 Each

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Description

EGFR-IN-158 (compound 12e) is an orally active EGFR inhibitor with an IC50 of 0.22 nM for EGFR (Del19/T790M) . EGFR-IN-158 inhibits phosphorylation and downstream signaling by binding to EGFR, thereby inhibiting the proliferation of tumor cell lines and promoting apoptosis[1].

UNSPSC

12352211

Target

Apoptosis; EGFR

Related Pathways

Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

C=CC(NC1=CC(NC2=NC=C(Cl)C(NC3=CC=CC=C3S(=O)(NCC)=O)=N2)=C(OC)C=C1N(CCN(C)C)C)=O

Molecular Formula

C27H35ClN8O4S

Molecular Weight

603.14

References & Citations

[1]Yao H, et al. Synthesis and evaluation of novel amino pyrimidine derivatives containing sulfonamide and their application as EGFR inhibitors. Bioorg Chem. 2025 Jun 15;160:108467.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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EGFR-IN-158

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