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EGFR-IN-158

CAT: 0931-T207640-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T207640-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Apoptosis, EGFR
Related Pathways
JAK/STAT signaling, Apoptosis, Tyrosine Kinase/Adaptors, Angiogenesis
Bioactivity
EGFR-IN-158 (compound 12e) is an orally active EGFR inhibitor with an IC50 value of 0.22 nM for EGFR (Del19/T790M) . By binding to EGFR, EGFR-IN-158 inhibits phosphorylation and downstream signaling, thereby suppressing the proliferation of tumor cell lines and promoting apoptosis.
Molecular Formula
C27H35ClN8O4S
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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