YXG-158

CAT: 0931-T79519-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0931-T79519-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2952994-34-0

Target

Androgen Receptor

Related Pathways

Endocrinology/Hormones

Bioactivity

YXG-158 (Compound 23-h), an orally active androgen receptor (AR) degrader and cytochrome P450 17A1 (CYP17A1) inhibitor, exhibits AR degradation with a DC50 of 1.28 μM and CYP17A1 inhibition with an IC50 of 100 nM. It is under investigation for potential use in research on enzalutamide-resistant prostate cancer [1].

Smiles

C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C(=CC3)C[C@@H](NC(=O)C5=CC=C(F)C=C5)CC4)(CC1)[H])[H])(CC=C2N6C=C(C)N=C6)[H]

Molecular Formula

C30H36FN3O

Molecular Weight

473.62

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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Catalog	Name
HY-155666	YXG-158
BA2774-5.1	PFK-158
MBS5780069	BF-158
cyt-179-01	IL36A 158 a.a.
BC5	BPC 158
120009	Msp-158
HY-172795	EGFR-IN-158
cyt-958-01	msRANKL (158-316)

YXG-158

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