YXG-158

• Target:

  Androgen Receptor

• Related Pathways:

  Endocrinology/Hormones

• Bioactivity:

  YXG-158 (Compound 23-h), an orally active androgen receptor (AR) degrader and cytochrome P450 17A1 (CYP17A1) inhibitor, exhibits AR degradation with a DC50 of 1.28 ?M and CYP17A1 inhibition with an IC50 of 100 nM. It is under investigation for potential use in research on enzalutamide-resistant prostate cancer [1].

• Smiles:

  C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C(=CC3)C[C@@H](NC(=O)C5=CC=C(F)C=C5)CC4)(CC1)[H])[H])(CC=C2N6C=C(C)N=C6)[H]

• Molecular Formula:

  C30H36FN3O

• Molecular Weight:

  473.62

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2952994-34-0