MDM2/XIAP-IN-3

• UNSPSC Description:

  MDM2/XIAP-IN-3 (compound 3e) is a dual MDM2/XIAP inhibitor. MDM2/XIAP-IN-3 reduces MDM2 and XIAP protein levels and increases p53 expression, thereby inhibiting cancer cell growth and causing cell death[1].

• Target Antigen:

  IAP; MDM-2/p53

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/mdm2-xiap-in-3.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=S(C1=CC2=C(NC(C3=CC=C(C(C(C)C)=O)C=C3)C4C2OCC4)C=C1)(NC5=CC=CC(C(C)=O)=C5)=O

• Molecular Weight:

  518.62

• References & Citations:

  [1]Albadari N, et al. Synthesis and biological evaluation of dual MDM2/XIAP inhibitors based on the tetrahydroquinoline scaffold. Eur J Med Chem. 2023 Jul 5;255:115423.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2925583-17-9