MDM2/XIAP-IN-2

MDM2/XIAP-IN-2

• CAS Number: 2761969-85-9
• UNSPSC Description: MDM2/XIAP-IN-2 is a dual inhibitor of murine double minute 2 (MDM2) and X-linked inhibitor of apoptosis protein (XIAP). MDM2/XIAP-IN-2 degrades MDM2, and inhibits XIAP mRNA translation to inhibits cancer cells. Particularly, MDM2/XIAP-IN-2 inhibits acute lymphoblastic leukemia cell line EU-1 with an IC50 value of 0.3 μM[1].
• Target Antigen: MDM-2/p53
• Type: Reference compound
• Related Pathways: Apoptosis
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/mdm2-xiap-in-2.html
• Solubility: 10 mM in DMSO
• Smiles: O=S(C1=CC2=C(NC(C3=CC=C(C(C(C)C)=O)C=C3)C4C2OCC4)C=C1)(NC5=CC=C(C)C(C)=C5)=O
• Molecular Weight: 504.64
• References & Citations: [1]Wu Z, et al. Discovery of N-(3, 4-Dimethylphenyl)-4-(4-isobutyrylphenyl)-2, 3, 3a, 4, 5, 9b-hexahydrofuro [3, 2-c] quinoline-8-sulfonamide as a Potent Dual MDM2/XIAP Inhibitor[J]. Journal of medicinal chemistry, 2021, 64(4): 1930-1950.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported