MDM2/4-p53-IN-3

• UNSPSC Description:

  MDM2/4-p53-IN-3 is a MDM2/4-p53 protein-protein interactions (PPIs) inhibitor (IC50s: 18.5 nM for MDM2-p53, 14.8 nM for MDM4-p53). MDM2/4-p53-IN-3 can be used in the research of cancers, such as colon cancer[1].

• Target Antigen:

  MDM-2/p53

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/mdm2-4-p53-in-3.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C([C@@H]1C2=CC=CC(Cl)=C2F)=NN(C3CCCCC3)[C@@]41C(NC5=C4C=CC(Cl)=C5)=O)OCC

• Molecular Weight:

  504.38

• References & Citations:

  [1]Margarida Espadinha, et al. Discovery of MDM2-p53 and MDM4-p53 protein-protein interactions small molecule dual inhibitors. Eur J Med Chem. 2022 Aug 5;241:114637.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported