p53-MDM2-IN-3

p53-MDM2-IN-3

• CAS Number: 1542066-74-9
• UNSPSC Description: p53-MDM2-IN-3 (Compound 5s) is an orally active p53-MDM2 inhibitor with a Ki value of 0.25 μM. p53-MDM2-IN-3 exerts antitumor activity by inhibiting NF-κB pathway[1].
• Target Antigen: MDM-2/p53; NF-κB
• Type: Reference compound
• Related Pathways: Apoptosis;NF-κB
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/p53-mdm2-in-3.html
• Solubility: 10 mM in DMSO
• Smiles: O=C1C2=C(C(N1CCCN3C=NC=C3)C4=CC=C(C=C4)Br)C(C5=CC=CC=C5)=NN2CC6=CC=C(C=C6)F
• Molecular Weight: 570.45
• References & Citations: [1]Zhuang C, et al. Double-edged swords as cancer therapeutics: novel, orally active, small molecules simultaneously inhibit p53-MDM2 interaction and the NF-κB pathway. J Med Chem. 2014 Feb 13;57(3):567-77.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported