XIAP BIR2/BIR2-3 inhibitor-1

• UNSPSC Description:

  XIAP BIR2/BIR2-3 inhibitor-1 (compound 3) is a dual inhibitor of BIR2 and BIR2-3 with IC50s of 1.9 and 0.8 nM, respectively. XIAP BIR2/BIR2-3 inhibitor-1 can used in study cancers[1].

• Target Antigen:

  IAP

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/xiap-bir2-bir2-3-inhibitor-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(N1[C@@](C(N[C@H](C(N[C@H](CCCN2C=C(CO[C@@](CCN3C([C@H](C(C)(C)C)NC([C@H](C)NC)=O)=O)([H])[C@@]3([H])C4=O)N=N2)C(O)=O)=O)CC5=CC(C=CC=C6)=C6C=C5)=O)([H])[C@@](OCC7=CN(CCC[C@@H](NC([C@@H](N4)CC8=CC(C=CC=C9)=C9C=C8)=O)C(O)=O)N=N7)([H])CC1)[C@H](C(C)(C)C)NC([C@H](C)NC)=O

• Molecular Weight:

  1409.63

• References & Citations:

  [1]Robert M. Borzilleri, et al. Macrocyclic compounds for inhibition of inhibitors of apoptosis. WO2014074665A1. 2014-05-15.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1609384-59-9