BRD4 degrader-3
CAT:
804-HY-136857-02
Size:
5 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
BRD4 degrader-3
- CAS Number: 2413382-30-4
- UNSPSC Description: BRD4 degrader-3 is a potent bromodomain BRD4 degrader extracted from patent WO2020055976A1, example 1a, has IC50s of 15.5 and 12.3 nM for BRD4-BD1 and BRD4-BD2, respectively[1]. PROTAC BRD4 Degrader-7 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Target Antigen: Epigenetic Reader Domain
- Type: Reference compound
- Related Pathways: Epigenetics
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/brd4-degrader-3.html
- Smiles: O=C(OC(C)(C)C)C[C@H]1C2=NN=C(C)N2C3=C(C(C)=C(C)S3)C(C4=CC=C(C#CCN)C=C4)=N1
- Molecular Weight: 475.61
- References & Citations: [1]Robert Anthony BLAKE, et al. Tert-butyl (s)-2-(4-(phenyl)-6h-thieno[3,2-f][1,2,4]triazolo[4,3-a] [1,4]diazepin-6-yl) acetate derivatives and related compounds as bromodomain brd4 inhibitors for treating cancer. WO2020055976A1.
- Shipping Conditions: Room Temperature