A09-003

CAT: 0804-HY-155245-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-155245-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A09-003 is a CDK-9 inhibitor (IC50: 16 nM) . A09-003 inhibits leukemia cell proliferation (IC50: 1.90, 0.86, 2.49, 1.84, 0.48 μM for BDCM, Molm-14, THP-1, U937, MV4-11 cells) . A09-003 induces apoptosis and decreases Mcl-1 expression through Thr163 dephosphorylation[1].
CAS Number
[2911646-14-3]
UNSPSC
12352005
Target
Bcl-2 Family; CDK
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/a09-003.html
Solubility
10 mM in DMSO
Smiles
COC1=CC=CC=C1C2=CC=NC(NC3=CC=CC(N4CCCNCC4)=C3)=C2
Molecular Formula
C23H26N4O
Molecular Weight
374.48
References & Citations
[1]Sim KM, et al. A new cyclin-dependent kinase-9 inhibitor A09-003 induces apoptosis in acute myeloid leukemia cells with reduction of myeloid cell leukemia sequence-1 protein. Chem Biol Interact. 2023 Sep 1;382:110554.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Mcl-1

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