A09-003

• Description :

  A09-003 is a CDK-9 inhibitor (IC50: 16 nM) . A09-003 inhibits leukemia cell proliferation (IC50: 1.90, 0.86, 2.49, 1.84, 0.48 μM for BDCM, Molm-14, THP-1, U937, MV4-11 cells) . A09-003 induces apoptosis and decreases Mcl-1 expression through Thr163 dephosphorylation[1].

• UNSPSC :

  12352005

• Target :

  Bcl-2 Family; CDK

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Cell Cycle/DNA Damage

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/a09-003.html

• Solubility :

  10 mM in DMSO

• Smiles :

  COC1=CC=CC=C1C2=CC=NC(NC3=CC=CC(N4CCCNCC4)=C3)=C2

• Molecular Formula :

  C23H26N4O

• Molecular Weight :

  374.48

• References & Citations :

  [1]Sim KM, et al. A new cyclin-dependent kinase-9 inhibitor A09-003 induces apoptosis in acute myeloid leukemia cells with reduction of myeloid cell leukemia sequence-1 protein. Chem Biol Interact. 2023 Sep 1;382:110554.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Mcl-1

• CAS Number :

  [2911646-14-3]