A09-003

A09-003

• CAS Number: 2911646-14-3
• UNSPSC Description: A09-003 is a CDK-9 inhibitor (IC50: 16 nM). A09-003 inhibits leukemia cell proliferation (IC50: 1.90, 0.86, 2.49, 1.84, 0.48 μM for BDCM, Molm-14, THP-1, U937, MV4-11 cells). A09-003 induces apoptosis and decreases Mcl-1 expression through Thr163 dephosphorylation[1].
• Target Antigen: Bcl-2 Family; CDK
• Type: Reference compound
• Related Pathways: Apoptosis;Cell Cycle/DNA Damage
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/a09-003.html
• Solubility: 10 mM in DMSO
• Smiles: COC1=CC=CC=C1C2=CC=NC(NC3=CC=CC(N4CCCNCC4)=C3)=C2
• Molecular Weight: 374.48
• References & Citations: [1]Sim KM, et al. A new cyclin-dependent kinase-9 inhibitor A09-003 induces apoptosis in acute myeloid leukemia cells with reduction of myeloid cell leukemia sequence-1 protein. Chem Biol Interact. 2023 Sep 1;382:110554.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported