CS-003

CAT: 0804-HY-19633ASize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-19633ASize:1 Each
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CS-003 is a triple neurokinin receptor antagonist with activity in inhibiting neurokinin-related respiratory diseases. CS-003 exhibits high affinity for human neurokinin 1, 2 and 3 receptors, withKi values of 2.3 nM, 0.54 nM and 0.74 nM respectively. The Ki values of CS-003 on the guinea pig neurokinin receptor are 5.2 nM, 0.47 nM and 0.71 nM respectively, showing superior inhibitory effect. CS-003 significantly inhibits the formation of inositol phosphate involving substance P, neurokinin A and neurokinin B through competitive antagonism. CS-003 significantly inhibits citric acid-induced cough, and its effect is better than other selective neurokinin receptor antagonists[1].
CAS Number
[216776-73-7]
UNSPSC
12352005
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cs-003.html
Smiles
O=S1C2(CCN(CC2)CC[C@@]3(C4=CC(Cl)=C(C=C4)Cl)CN(CCO3)C(C5=CC(OC)=C(C(OC)=C5)OC)=O)C6=CC=CC=C6C1.Cl
Molecular Formula
C34H39Cl3N2O6S
Molecular Weight
710.11
References & Citations
[1]Novel triple neurokinin receptor antagonist CS-003 strongly inhibits neurokinin related responses
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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