CS-003

• Description :

  CS-003 is a triple neurokinin receptor antagonist with activity in inhibiting neurokinin-related respiratory diseases. CS-003 exhibits high affinity for human neurokinin 1, 2 and 3 receptors, withKi values of 2.3 nM, 0.54 nM and 0.74 nM respectively. The Ki values of CS-003 on the guinea pig neurokinin receptor are 5.2 nM, 0.47 nM and 0.71 nM respectively, showing superior inhibitory effect. CS-003 significantly inhibits the formation of inositol phosphate involving substance P, neurokinin A and neurokinin B through competitive antagonism. CS-003 significantly inhibits citric acid-induced cough, and its effect is better than other selective neurokinin receptor antagonists[1].

• UNSPSC :

  12352005

• Target :

  Endogenous Metabolite

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/cs-003.html

• Smiles :

  O=S1C2(CCN(CC2)CC[C@@]3(C4=CC(Cl)=C(C=C4)Cl)CN(CCO3)C(C5=CC(OC)=C(C(OC)=C5)OC)=O)C6=CC=CC=C6C1.Cl

• Molecular Formula :

  C34H39Cl3N2O6S

• Molecular Weight :

  710.11

• References & Citations :

  [1]Novel triple neurokinin receptor antagonist CS-003 strongly inhibits neurokinin related responses

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [216776-73-7]