CS-003 (Free base)

CS-003 (Free base)

• CAS Number: 191672-52-3
• UNSPSC Description: CS-003 Free base (CS-003), a triple tachykinin receptor antagonist, shows high affinities for human (Neurokinin) NK1, NK2 and NK3 receptors with Ki values of 2.3 nM, 0.54 nM and 0.74 nM, respectively. CS-003 Free base (CS-003) has therapeutic efficacy on respiratory diseases associated with neurokinins.
• Target Antigen: Neurokinin Receptor
• Type: Reference compound
• Related Pathways: GPCR/G Protein;Neuronal Signaling
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Infection; Endocrinology
• Assay Protocol: https://www.medchemexpress.com/cs-003-free-base.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(N1C[C@@](CCN2CCC3(CC2)C4=CC=CC=C4C[S@@]3=O)(C5=CC=C(Cl)C(Cl)=C5)OCC1)C6=CC(OC)=C(OC)C(OC)=C6
• Molecular Weight: 673.65
• References & Citations: [1]Tsuchida H, et al. Novel triple neurokinin receptor antagonist CS-003 strongly inhibits neurokinin related responses. Eur J Pharmacol. 2008 May 31;586(1-3):306-12.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported