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DF-003

CAT: 0013-GTR19273349-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19273349-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DF-003 is a selective, orally active, ATP-competitive ALPK1 inhibitor capable of crossing the blood-brain barrier. It effectively inhibits human ALPK1 and ALPK1[T237M] with IC50 values of 1.5 nM and 16 nM, respectively. The compound exhibits selectivity over the nearest kinase by more than 860-fold. DF-003 suppresses the upregulation of TNF, CXCL10, or CXCL8 in HEK-293 cells. It has applications in the study of retinopathy, optic nerve edema, splenomegaly, anhidrosis, and headaches associated with ROSAH syndrome.
CAS Number
2765462-07-3
Smiles
[C@] (C#C) (C) (C=1N=C (NC (=O) C2=C (F) C=C (C=C2F) N3CCNCC3) SC1) C4=CC=C (Cl) C=C4
Molecular Formula
C24H21ClF2N4OS
Molecular Weight
486.97
Storage Conditions
-20°C
Notes
For research use only.

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