MRK 003

• Description :

  MRK 003 is a potent, selective and orally active γ-secretase inhibitor. MRK 003 reduce brain Aβ production in vivo. MRK 003 induces caspase-dependent apoptosis and inhibits tumor cell proliferation in vivo and in vitro[1][2][3].

• UNSPSC :

  12352005

• Target :

  Apoptosis; γ-secretase

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Neuronal Signaling; Stem Cell/Wnt

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Cancer; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/mrk-003.html

• Smiles :

  FC(F)(F)CN(C[C@]1(N2)[C@H]3CC4=C(C=CC(/C=C/CN5CCC(C(F)(F)F)CC5)=C4)C[C@@H]1CC3)S2(=O)=O

• Molecular Formula :

  C25H31F6N3O2S

• Molecular Weight :

  551.59

• References & Citations :

  [1]Lewis HD, et al. Apoptosis in T cell acute lymphoblastic leukemia cells after cell cycle arrest induced by pharmacological inhibition of notch signaling. Chem Biol. 2007;14 (2) :209-219.|[2]Sparey T, et al. Cyclic sulfamide gamma-secretase inhibitors. Bioorg Med Chem Lett. 2005;15 (19) :4212-4216.|[3]Mizuma M, et al. The gamma secretase inhibitor MRK-003 attenuates pancreatic cancer growth in preclinical models. Mol Cancer Ther. 2012;11 (9) :1999-2009.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [623165-93-5]