EYE-003

CAT: 0804-HY-175664Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-175664Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
EYE-003 is an orally active RPE65 inhibitor with an IC50 of 102 nM. EYE-003 regulates the visual cycle in mice by reducing 11-cis-retinal (11cRAL) (HY-116711) synthesis and increasing all-trans-retinyl esters (atREs) . EYE-003 suppresses scotopic ERG b-wave amplitude and exerts protective effects against retinal degeneration in Abca4⁻/⁻ Rdh8⁻/⁻ mice (a STGD1 model) by reducing retinal autofluorescent puncta and preserving outer nuclear layer (ONL) thickness in a dose-dependent manner. EYE-003 can be used for the study of visual cycle-associated retinopathies, such as Stargardt disease type 1 (STGD1) [1].
UNSPSC
12352100
Target
RPE65
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Metabolic Disease
Smiles
O=CO.CCCC(CCC)C(OC1=CC=CC(C(O)CCN)=C1)=O
Molecular Formula
C18H29NO5
Molecular Weight
339.43
References & Citations
[1]Bassetto M, et al. Rationally Designed, Short-Acting RPE65 Inhibitors for Visual Cycle-Associated Retinopathies. J Med Chem. 2025 Aug 28;68 (16) :17638-17652.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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