MAT2A-IN-11

• Description:

  MAT2A Allosteric inhibitor 1 (compound 5) is a MAT2A selective inhibitor of methionine adenosyltransferase (MAT) with an IC50 of 6.8 nM[1].

• UNSPSC:

  12352005

• Target:

  Methionine Adenosyltransferase (MAT)

• Type:

  Reference compound

• Related Pathways:

  Epigenetics; Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/mat2a-in-11.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CCN1N=C2C (C=CC (NC (C3=CC (C4CC4) =NC5=C3C=NN5CC) =O) =C2) =C1

• Molecular Formula:

  C21H22N6O

• Molecular Weight:

  374.44

• References & Citations:

  [1]Kalliokoski T, et al. Discovery of novel methionine adenosyltransferase 2A (MAT2A) allosteric inhibitors by structure-based virtual screening. Bioorg Med Chem Lett. 2023 Oct 1;94:129450..

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported