MAT2A-IN-11

• Description :

  MAT2A Allosteric inhibitor 1 (compound 5) is a MAT2A selective inhibitor of methionine adenosyltransferase (MAT) with an IC50 of 6.8 nM[1].

• UNSPSC :

  12352005

• Target :

  Methionine Adenosyltransferase (MAT)

• Type :

  Reference compound

• Related Pathways :

  Epigenetics; Metabolic Enzyme/Protease

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/mat2a-in-11.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CCN1N=C2C(C=CC(NC(C3=CC(C4CC4)=NC5=C3C=NN5CC)=O)=C2)=C1

• Molecular Formula :

  C21H22N6O

• Molecular Weight :

  374.44

• References & Citations :

  [1]Kalliokoski T, et al. Discovery of novel methionine adenosyltransferase 2A (MAT2A) allosteric inhibitors by structure-based virtual screening. Bioorg Med Chem Lett. 2023 Oct 1;94:129450..

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported