MAT2A-IN-13

• UNSPSC Description:

  MAT2A-IN-13 is a potent and orally active methionine adenosyltransferase 2A (MAT2A) inhibitor with a favorable pharmacokinetic profile. MAT2A-IN-13 shows in vivo potency in an HCT-116 MTAP-deleted xenograft model. MAT2A-IN-13 can be used for MTAP-Deleted tumors treatment research[1].

• Target Antigen:

  Methionine Adenosyltransferase (MAT)

• Type:

  Reference compound

• Related Pathways:

  Epigenetics;Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/mat2a-in-13.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1C(C2=CC=CN=C2F)=C(C=C(C(F)(F)F)C=C3)N3C(NC4CC4)=N1

• Molecular Weight:

  364.30

• References & Citations:

  [1]Qun Li, et al. Discovery of Potent and Oral Bioavailable MAT2A Inhibitors for the Treatment of MTAP-Deleted Tumors. ACS Med Chem Lett. 2023 Dec 4;14(12):1876-1881.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2851449-24-4