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MAT2A-IN-13

CAT: 0804-HY-162010Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-162010Size:1 Each
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Description
MAT2A-IN-13 is a potent and orally active methionine adenosyltransferase 2A (MAT2A) inhibitor with a favorable pharmacokinetic profile. MAT2A-IN-13 shows in vivo potency in an HCT-116 MTAP-deleted xenograft model. MAT2A-IN-13 can be used for MTAP-Deleted tumors treatment research[1].
CAS Number
2851449-24-4
UNSPSC
12352005
Target
Methionine Adenosyltransferase (MAT)
Type
Reference compound
Related Pathways
Epigenetics; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mat2a-in-13.html
Solubility
10 mM in DMSO
Smiles
O=C1C(C2=CC=CN=C2F)=C(C=C(C(F)(F)F)C=C3)N3C(NC4CC4)=N1
Molecular Formula
C17H12F4N4O
Molecular Weight
364.30
References & Citations
[1]Qun Li, et al. Discovery of Potent and Oral Bioavailable MAT2A Inhibitors for the Treatment of MTAP-Deleted Tumors. ACS Med Chem Lett. 2023 Dec 4;14 (12) :1876-1881.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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