MAT2A-IN-13

MAT2A-IN-13

• CAS Number: 2851449-24-4
• UNSPSC Description: MAT2A-IN-13 is a potent and orally active methionine adenosyltransferase 2A (MAT2A) inhibitor with a favorable pharmacokinetic profile. MAT2A-IN-13 shows in vivo potency in an HCT-116 MTAP-deleted xenograft model. MAT2A-IN-13 can be used for MTAP-Deleted tumors treatment research[1].
• Target Antigen: Methionine Adenosyltransferase (MAT)
• Type: Reference compound
• Related Pathways: Epigenetics;Metabolic Enzyme/Protease
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/mat2a-in-13.html
• Solubility: 10 mM in DMSO
• Smiles: O=C1C(C2=CC=CN=C2F)=C(C=C(C(F)(F)F)C=C3)N3C(NC4CC4)=N1
• Molecular Weight: 364.30
• References & Citations: [1]Qun Li, et al. Discovery of Potent and Oral Bioavailable MAT2A Inhibitors for the Treatment of MTAP-Deleted Tumors. ACS Med Chem Lett. 2023 Dec 4;14(12):1876-1881.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported