MAT2A-IN-23

• Description:

  MAT2A-IN-23 (compound 39) is a MAT2A inhibitor, with an IC50 of 4 nM. MAT2A-IN-23 inhibits SAM in the HCT-116 (MTAP−/−) and in the HCT-116 WT cell line with IC50s of 3 and 2 nM, respectively. MAT2A-IN-23 inhibits SDMA in the HCT-116 (MTAP−/−) and in the HCT-116 WT cell line with IC50s of 2 and >3000 nM, respectively. MAT2A-IN-23 inhibits HCT-116 (MTAP−/−) cell proliferation with with an IC50 of 47 nM[1].

• UNSPSC:

  12352005

• Target:

  Methionine Adenosyltransferase (MAT)

• Related Pathways:

  Epigenetics; Metabolic Enzyme/Protease

• Field of Research:

  Cancer

• Smiles:

  O=C1[C@]2 (C3=CC (C (F) (C) F) =CC=C3C (NC ([2H]) ([2H]) [2H]) =N1) C4=CC=CN=C4CC2

• Molecular Formula:

  C19H14D3F2N3O

• Molecular Weight:

  344.37

• References & Citations:

  [1]Yang S, et al. Discovery of Novel Spirocyclic MAT2A Inhibitors Demonstrating High In Vivo Efficacy in MTAP-Null Xenograft Models. J Med Chem. 2025 Feb 13;68 (3) :3480-3494.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• CAS Number:

  2925324-58-7