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MAT2A-IN-10

CAT: 0804-HY-149915Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-149915Size:1 Each
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Description
MAT2A-IN-10 (Compound 28) is an orally active MAT2A inhibitor with an IC50 of 26 nM. MAT2A-IN-10 can be used for the research of cancer[1].
CAS Number
2924825-23-8
UNSPSC
12352005
Target
Methionine Adenosyltransferase (MAT)
Type
Reference compound
Related Pathways
Epigenetics; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mat2a-in-10.html
Solubility
10 mM in DMSO
Smiles
CCOC1=NC2=C(C(N(C(N2C3=CC=C(C=C3)OC(F)F)=O)C4=CC=C5N=C6CN(CCN6C5=C4)C)=O)C=C1
Molecular Formula
C27H24F2N6O4
Molecular Weight
534.51
References & Citations
[1]Zhang S, et al. Design and Structural Optimization of Methionine Adenosyltransferase 2A (MAT2A) Inhibitors with High In Vivo Potency and Oral Bioavailability. J Med Chem. 2023 Apr 13;66 (7) :4849-4867.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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