MAT2A-IN-10

• UNSPSC Description:

  MAT2A-IN-10 (Compound 28) is an orally active MAT2A inhibitor with an IC50 of 26 nM. MAT2A-IN-10 can be used for the research of cancer[1].

• Target Antigen:

  Methionine Adenosyltransferase (MAT)

• Type:

  Reference compound

• Related Pathways:

  Epigenetics;Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/mat2a-in-10.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CCOC1=NC2=C(C(N(C(N2C3=CC=C(C=C3)OC(F)F)=O)C4=CC=C5N=C6CN(CCN6C5=C4)C)=O)C=C1

• Molecular Weight:

  534.51

• References & Citations:

  [1]Zhang S, et al. Design and Structural Optimization of Methionine Adenosyltransferase 2A (MAT2A) Inhibitors with High In Vivo Potency and Oral Bioavailability. J Med Chem. 2023 Apr 13;66(7):4849-4867.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2924825-23-8