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EGFR-IN-79

CAT: 0804-HY-155074Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-155074Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
EGFR-IN-79 (compound 21) is an EGFR inhibior with antitumor activity. EGFR-IN-79 induces ROS-independent apoptosis and EGFR/AKT/mTOR-mediated autophagy. EGFR-IN-79 induces cell death at both proliferating and quiescent zones of EJ28 spheroids. EGFR-IN-79 exhibits safety profile in the zebrafish-based model[1].
UNSPSC
12352005
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-in-79.html
Solubility
10 mM in DMSO
Smiles
ClC1=CC=C(O)C(C2=CC(/C=C/C3=CC=CC([N+]([O-])=O)=C3)=NN2C4=CC=CC=C4)=C1
Molecular Formula
C23H16ClN3O3
Molecular Weight
417.84
References & Citations
[1]Leong SW, et al. Discovery of a novel dual functional phenylpyrazole-styryl hybrid that induces apoptotic and autophagic cell death in bladder cancer cells. Eur J Med Chem. 2023 Jun 5;254:115335.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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sc-19602 LMECA-79 (MECA-79) L
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sc-19602 FITCMECA-79 (MECA-79) FITC
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