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NLRP3-IN-79

CAT: 0804-HY-174270Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-174270Size:1 Each
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Description
NLRP3-IN-79 is an orally active NLRP3 inhibitor. NLRP3-IN-79 inhibits NLRP3 inflammasome with an IC50 of 10.69 nM. NLRP3-IN-79 blocks NLRP3 inflammasome assembly by directly binding to NLRP3 and disrupting the NEK7-NLRP3 interaction. NLRP3-IN-79 can be used for the study of NLRP3-driven diseases model, including systemic inflammation, peritonitis, and colitis[1].
CAS Number
3088796-72-6
UNSPSC
12352005
Target
Interleukin Related; NEKs; NOD-like Receptor (NLR)
Related Pathways
Cell Cycle/DNA Damage; Immunology/Inflammation
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology
Smiles
CCNC(N(CC1=CN=CC=C1)CC(NC2=C3C(CCC3)=CC4=C2CCC4)=O)=O
Molecular Formula
C23H28N4O2
Molecular Weight
392.49
References & Citations
[1]Lv Q, et al. Discovery of novel non-sulfonylurea NLRP3 inflammasome inhibitors for the treatment of multiple inflammatory diseases. Eur J Med Chem. 2025 Oct 5;295:117783.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-1; IL-18; NEK7; NLRP3

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