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HQL-79

CAT: 0804-HY-108259-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-108259-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HQL-79, a potent, selective and orally active human hematopoietic prostaglandin D synthase (H-PGDS) inhibitor, highly selectively inhibits the synthesis of PGD2, and acts as an anti-allergic agent, with a Kd of 0.8 μM and an IC50 of 6 μM. Shows no obvious effect on COX-1, COX-2, m-PGES, or L-PGDS[1].
CAS Number
162641-16-9
UNSPSC
12352005
Target
PGE synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/hql-79.html
Purity
99.89
Solubility
DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
N1(CCCC2=NN=NN2)CCC(OC(C3=CC=CC=C3)C4=CC=CC=C4)CC1
Molecular Formula
C22H27N5O
Molecular Weight
377.48
References & Citations
[1]Aritake K, et al. Structural and functional characterization of HQL-79, an orally selective inhibitor of human hematopoietic prostaglandin D synthase. J Biol Chem. 2006 Jun 2;281 (22) :15277-86. Epub 2006 Mar 17.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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Alternative Products

CatalogName
MBS5754971HQL-79
B7421-50HQL 79
A12992-5HQL-79 5mg
A12992-10HQL-79 10mg
A12992-2HQL-79 2mg
A12992-100HQL-79 100mg
A12992-25HQL-79 25mg
A12992-50HQL-79 50mg
sc-19602MECA-79 (MECA-79)
sc-19602 LMECA-79 (MECA-79) L

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