IR-251

CAT: 0931-T79284-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0931-T79284-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Others|||Reactive Oxygen Species|||Mitochondrial Metabolism|||PPAR|||Wnt/beta-catenin
Related Pathways
NF-?B|||Others|||Cytoskeletal Signaling|||Metabolism|||Stem Cells|||DNA Damage/DNA Repair|||Immunology/Inflammation
Bioactivity
IR-251 is a mitochondrion-targeting near-infrared (NIR) fluorescent probe that selectively accumulates in tumor cell mitochondria through organic anion transporting polypeptides (OATPs), leading to mitochondrial dysfunction. By impeding peroxisome proliferator-activated receptor gamma (PPAR?), IR-251 promotes reactive oxygen species (ROS) overproduction, consequently inhibiting the ?-catenin signaling pathway as well as associated cell cycle and metastasis proteins. This mechanism contributes to the compound's ability to suppress tumor growth and metastasis [1].
Molecular Formula
C51H70BrClN4O2
Molecular Weight
886.48
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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