IR-251

• Target :

  Others|||Reactive Oxygen Species|||Mitochondrial Metabolism|||PPAR|||Wnt/beta-catenin

• Related Pathways :

  NF-?B|||Others|||Cytoskeletal Signaling|||Metabolism|||Stem Cells|||DNA Damage/DNA Repair|||Immunology/Inflammation

• Bioactivity :

  IR-251 is a mitochondrion-targeting near-infrared (NIR) fluorescent probe that selectively accumulates in tumor cell mitochondria through organic anion transporting polypeptides (OATPs), leading to mitochondrial dysfunction. By impeding peroxisome proliferator-activated receptor gamma (PPAR?), IR-251 promotes reactive oxygen species (ROS) overproduction, consequently inhibiting the ?-catenin signaling pathway as well as associated cell cycle and metastasis proteins. This mechanism contributes to the compound's ability to suppress tumor growth and metastasis [1].

• Molecular Formula :

  C51H70BrClN4O2

• Molecular Weight :

  886.48

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C