IR-251

CAT: 0931-T79284-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0931-T79284-01Size:5 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Target

Others, Reactive Oxygen Species, Mitochondrial Metabolism, PPAR, Wnt/beta-catenin

Related Pathways

NF-κB, Others, Cytoskeletal Signaling, Metabolism, Stem Cells, DNA Damage/DNA Repair, Immunology/Inflammation

Bioactivity

IR-251 is a mitochondrion-targeting near-infrared (NIR) fluorescent probe that selectively accumulates in tumor cell mitochondria through organic anion transporting polypeptides (OATPs), leading to mitochondrial dysfunction. By impeding peroxisome proliferator-activated receptor gamma (PPARγ), IR-251 promotes reactive oxygen species (ROS) overproduction, consequently inhibiting the β-catenin signaling pathway as well as associated cell cycle and metastasis proteins. This mechanism contributes to the compound's ability to suppress tumor growth and metastasis [1].

Molecular Formula

C51H70BrClN4O2

Molecular Weight

886.48

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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HY-155062	IR-251
524488-01	IR
B2718-25	AM-251
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TRC-A575805-5MG	AM 251
GTR19174888-01	KPT-251
GTR19193513-01	MK-251
BA3153-50	RRD-251
164589	KPT 251

IR-251

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