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RRD-251

CAT: 0804-HY-117737A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-117737A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RRD-251 is an inhibitor of retinoblastoma tumor suppressor protein (Rb) -Raf-1 interaction, with potent anti-proliferative, anti-angiogenic and anti-tumor activities[1].
CAS Number
72214-67-6
Product Name Alternative
SR1378, 7-Deazaadenosine
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Raf
Type
Reference compound
Related Pathways
Apoptosis; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rrd-251.html
Concentration
10mM
Purity
99.87
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
NC(SCC1=CC=C(Cl)C=C1Cl)=N.[H]Cl
Molecular Formula
C8H9Cl3N2S
Molecular Weight
271.59
Precautions
H302, H315, H319, H335
References & Citations
[1]Sandeep Singh, et al. Rb-Raf-1 interaction disruptor RRD-251 induces apoptosis in metastatic melanoma cells and synergizes with dacarbazine. Mol Cancer Ther. 2010 Dec; 9 (12) : 3330–3341.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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