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DPP-4-IN-8

CAT: 0804-HY-155027Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-155027Size:1 Each
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Description
DPP-4-IN-8 (compound 27) is a potent and selective DPP4 (dipeptidyl peptidase 4) inhibitor, with a Ki of 0.96 μM. DPP-4-IN-8 blocks the dipeptidase activity of DPP4 in both Caco-2 and HepG-2 cells. DPP-4-IN-8 also dose-dependently suppresses the expression levels of the chemokines tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-1β (IL-1β) [1].
UNSPSC
12352005
Target
Dipeptidyl Peptidase; Interleukin Related; TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/dpp-4-in-8.html
Solubility
10 mM in DMSO
Smiles
[O-][N+](C1=CC(C(/C=C/C2=C(OC)C=C(O)C(Cl)=C2)=O)=CC=C1O)=O
Molecular Formula
C16H12ClNO6
Molecular Weight
349.72
References & Citations
[1]Li CQ, et al. Licochalcone A Derivatives as Selective Dipeptidyl Peptidase 4 Inhibitors with Anti-Inflammatory Effects. J Nat Prod. 2023 Jul 28;86 (7) :1824-1831.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DPP-4; IL-1; IL-6

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