DPP-4-IN-8

DPP-4-IN-8

• UNSPSC Description: DPP-4-IN-8 (compound 27) is a potent and selective DPP4 (dipeptidyl peptidase 4) inhibitor, with a Ki of 0.96 μM. DPP-4-IN-8 blocks the dipeptidase activity of DPP4 in both Caco-2 and HepG-2 cells. DPP-4-IN-8 also dose-dependently suppresses the expression levels of the chemokines tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-1β (IL-1β)[1].
• Target Antigen: Dipeptidyl Peptidase; Interleukin Related; TNF Receptor
• Type: Reference compound
• Related Pathways: Apoptosis;Immunology/Inflammation;Metabolic Enzyme/Protease
• Applications: COVID-19-immunoregulation
• Field of Research: Cancer; Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/dpp-4-in-8.html
• Solubility: 10 mM in DMSO
• Smiles: [O-][N+](C1=CC(C(/C=C/C2=C(OC)C=C(O)C(Cl)=C2)=O)=CC=C1O)=O
• Molecular Weight: 349.72
• References & Citations: [1]Li CQ, et al. Licochalcone A Derivatives as Selective Dipeptidyl Peptidase 4 Inhibitors with Anti-Inflammatory Effects. J Nat Prod. 2023 Jul 28;86(7):1824-1831.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported